Venous Thromboembolic Complications of Surgical Excision of Meningioma: A Retrospective Trial to Suggest Preoperative Risk Factors

Document Type : Original Articles

Authors

1 Department of Neurosurgery, Faculty of Medicine, Helwan University

2 Department of Neurosurgery, Faculty of Medicine, Tanta University

Abstract

Objectives: This retrospective study targets to assess the applicability of perioperative data for early prediction of the possibility of development of oncoming venous thromboembolic events after surgery for intracranial meningioma surgery (PO-VTE)
Patients and Methods: 464 files with complete perioperative data were reviewed for the development of PO-TVE and its relation to patients' demographic and clinical data, lesion-related data, preoperative, operative and postoperative data was analyzed.
Results: Files of 27 patients (5.82%) indicated the development of PO-VTE (VTE group). The incidence of PO-VTE was positively correlated with patients' age, body mass index (BMI), current smoking, presence of co-morbidities, paretic limb or recurrent intracranial lesion and with prolonged operative time and ICU stay and prolonged hospital stay was positively related to the development of VTE. The Receiver Operating Characteristic (ROC) curve analysis and Multivariate Regression analysis defined old age and presence of comorbidities as the most significant predictors. ROC curve analysis also defined recurrent meningioma and prolonged ICU stay as the significant predictors, but Multivariate analysis excluded prolonged ICU stay as a significant predictor for PO-VTE. Multivariate Regression analysis for combination of these variates defined older age, recurrent IC lesion and long recumbence in ICU as complementary factors for increasing the incidence of PO-VTE.
Conclusion: VTE events are not uncommon complication of meningioma excision. Older age and higher BMI are predictors for oncoming PO-VTE especially in patient had recurrent lesion, associated comorbidities and long ICU stay.

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